Molecular determinants of auto-immunity and immune adverse events in advanced cancer patients treated with immune checkpoint inhibitors.

Translational Research Study summary:

Immune checkpoint inhibitors are remarkably active in a variety of cancers. The hypothesis of this study is that a group of oncology patients with a genetic susceptibility to autoimmunity are more likely to develop an immune related adverse event (IRAEs) after treatment with immune checkpoint inhibitors. Aims are to study

  1. Baseline molecular predictors of immune-related adverse events (IRAEs),
  2. Identify common and rare genetic variants that segregate with IRAEs, and
  3. Changes in peripheral blood lymphocytes (effector, memory and regulatory subsets), and the kinetics and distribution of CTLA4 and PD-1 expression in patients with or without IRAEs.

AUTO-CHECK uses data and biospecimens from 6 multi-site investigator-initiated trials of immune checkpoint inhibitors across 4 co-operative trials groups (ALTG, ANZGOG, ANZUP and COGNO). These trials span 5 tumour types: mesothelioma (DREAM); NSCLC (NIVORAD and ILLUMINATE), endometrial (PHAEDRA), renal cell (KEYPAD) and glioblastoma (NUTMEG).

AUTO-CHECK: participating clinical trials (as at 4 July 2018)

Supported by:   Cancer Australia project grant, Genomics Cancer Clinical Trials Initiative,

                        ALTG, ANZGOG, ANZUP and COGNO

Participation:    Australia

Lead Group:     NHMRC CTC

Status:            Recruiting

Activation Date: June 2017

Chair:              Professor Matthew Cook (Australian National University, Canberra)


Study Committee   

  • Matthew Cook (CIA), immunologist, NHMRC Centre for Research Excellence in Personalised Immunology

  • Sonia Yip

  • Martin Stockler

  • Desmond Yip                      Canberra Hospital cohort             

  • Anna Nowak                      study chairDREAM          mesothelioma   ALTG

  • Paul Mitchell                     study chairNIVORAD     NSCLC                   ALTG

  • Yoland Antill                      study chairPHAEDRA     endometrial       ANZGOG

  • Daniel Andrews

  • Chee Lee

  • Craig Gedye                     study chairKEYPAD         renal cell              ANZUP

  • Mustafa Khasraw            study chairNUTMEG      glioblastoma      COGNO

  • Kristy Robledo                   statistician          

  • Michelle Parry                   project officer

  • Carola Vinuesa

  • Matthew Links

  • Sayed Ali

  • Joost Lesterhuis


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