Health Technology Assessment (HTA) reports


CTC researchers conduct health technology assessment (HTA) reports to address priority questions about the safety, effectiveness and cost-effectiveness of new clinical interventions or tests. These reports are used to provide the best available evidence to inform health policy decisions. They are commissioned by the Australian Department of Health and Ageing (DoHA) for the Medical Services Advisory Committee (MSAC) or other government committees.

Assisted reproductive technologies
Automated liquid based cytology
Brachytherapy for the treatment of prostate cancer
Breast magnetic resonance imaging
Capsule Endoscopy for the Diagnosis of Suspected Small Bowel Crohn's Disease
Computed tomography colonography (CTC)
Conformal radiotherapy
Coronary artery disease review
Drug-eluting stents
Endoluminal gastroplication for gastro-oesophageal reflux disease
Gamma knife radiosurgery
Human papilloma virus triage test for women with possible or definite low-grade squamous intra-epithelial lesions
Intravascular brachytherapy
Intravascular ultrasound
Laparoscopic adjustable gastric banding for morbid obesity
Lymphoedema review
Magnetic resonance cholangiopancreatography
Magnetic resonance imaging for staging cervical and endometrial cancer
Optical coherence tomography
Ostase
Paediatric liver transplantation
Peritonectomy
Peritonectomy with heated intraoperative intraperitoneal chemotherapy
Positron emission tomography for cervical cancer
Positron emission tomography for epilepsy
Positron emission tomography for glioma
Positron emission tomography for head and neck cancer
Positron emission tomography for lymphoma
Positron emission tomography for myocardial viability
Positron emission tomography for NSCLC and SPN
Positron emission tomography for oesophageal and gastric cancer
Positron emission tomography for recurrent colorectal, melanoma and ovarian cancer
Positron emission tomography for sarcoma
Pulmonary thromboendarterectomy
Selective dorsal rhizotomy
SIR-Spheres for the treatment of non-resectable liver tumours
Transurethral needle ablation for benign prostatic hyperplasia

Assisted reproductive technologies

Type of evaluation:Systematic review and economic model
Patient population:Couples with unexplained infertility or male factor infertility
Intervention: Assisted reproductive technologies (ARTs)
Comparator: Alternative ARTs strategies
Status:

Automated liquid based cytology

Type of evaluation:Systematic review and economic model
Patient population:Women presenting for cervical cytology
Intervention: Liquid-based cytology and automated image analysis
Comparator: Conventionally prepared Pap smear cytology and manual reading
Status: Considered by MSAC March 2009
ReportNumber:1122
Link to MSAC: click here

Brachytherapy for the treatment of prostate cancer

Type of evaluation:Systematic review
Patient population:Patients with early, localised prostate cancer.
Intervention: Brachytherapy (iodine-125 permanent implants)
Comparator: Radical prostatectomy, external beam radiation therapy, no initial treatment or deferred treatment ('active surveillance')
Status: Recommendations of the report were endorsed by the Commonwealth Minister for Health and Ageing on 28 November 2005.
ReportNumber:1089.1
Link to MSAC: click here

Breast magnetic resonance imaging

Type of evaluation:Systematic review and economic evaluation
Patient population:Asymptomatic women at high risk of breast cancer
Intervention: Breast magnetic resonance imaging as a screening test in addition to mammography and breast ultrasound
Comparator: Mammography with or without breast ultrasound
Status: Considered by MSAC November 2006.
ReportNumber:1098
Link to MSAC: click here

Capsule Endoscopy for the Diagnosis of Suspected Small Bowel Crohn's Disease

Type of evaluation:Systematic review and economic evaluation
Patient population:Patients with suspected but unconfirmed Crohn's disease
Intervention: Capsule Endoscopy
Comparator:Abdomen computed tomography with or without enterography or magnetic resonance imaging with or without enterography or empirical treatment
Status:
ReportNumber:1146.1
Link to MSAC: click here

Computed tomography colonography (CTC)

Type of evaluation:Systematic review and economic model
Patient population:i) Symptomatic patients and asymptomatic with high risk due to personal/family history of colorectal polyps or cancer; and ii) symptomatic or high-risk patients who are ineligible for colonoscopy due to patient contraindications or the inability to perform or complete the test (versus DCBE only)
Intervention: Computed tomography colonography (CTC)
Comparator: DCBE, colonoscopy
Status: Recommendations of the report were endorsed by the Commonwealth Minister for Health and Ageing on 24 August 2006.
ReportNumber:1095
Link to MSAC: click here

Conformal radiotherapy

Type of evaluation:Systematic review
Patient population:Prostate cancer, other cancers
Intervention: Conformal radiotherapy
Comparator: Conventional radiotherapy
Status:
ReportNumber:1038
Link to MSAC: click here

Coronary artery disease review

Type of evaluation:Horizon scanning
Patient population:
Intervention:
Comparator:
Status: Report published March 2003

Drug-eluting stents

Type of evaluation:Systematic review
Patient population:Patients with de novo coronary artery disease, with various prespecified subgroups
Intervention: Paclitaxel- or sirolimus-eluting stents
Comparator: Bare metal stents
Status: Recommendations of the report were endorsed by the Commonwealth Minister for Health and Ageing on 2 March 2005
ReportNumber:30
Link to MSAC: click here

Endoluminal gastroplication for gastro-oesophageal reflux disease

Type of evaluation:Systematic review and economic model
Patient population:Gastro-oesophageal reflux disease
Intervention: Endoluminal gastroplication (ELGP)
Comparator: Pharmacology and/or surgery
Status:
ReportNumber:1047
Link to MSAC: click here

Gamma knife radiosurgery

Type of evaluation:Systematic review
Patient population:Patients with pituitary adenomas, meningiomas, acoustic neuromas, arteriovenous malformations, primary malignant lesions, or cerebral metastases.
Intervention: Gamma knife radiosurgery
Comparator: Varied across indications (surgery, radiotherapy, Linac, Cyberknife, observation)
Status: Recommendations of the report were endorsed by the Commonwealth Minister for Health and Ageing on 3 November 2006.
ReportNumber:34
Link to MSAC: click here

Human papilloma virus triage test for women with possible or definite low-grade squamous intra-epithelial lesions

Type of evaluation:Systematic review and economic model
Patient population:Asymptomatic women with an index cytology result of a possible or definite low-grade squamous intra-epithelial lesion
Intervention: HPV triage test
Comparator: Follow-up cytology at 12 months
Status: Considered by MSAC March 2009
ReportNumber:39
Link to MSAC: click here

Intravascular brachytherapy

Type of evaluation:Systematic review and economic model
Patient population:Patients with coronary artery restensosis
Intervention: Catheter-based intravascular brachytherapy
Comparator: Other types of percutaneous interventions
Status:
ReportNumber:1041
Link to MSAC: click here

Intravascular ultrasound

Type of evaluation:Systematic review, decision analysis and economic model
Patient population:Coronary artery disease (diagnosis of and, during intervention, for the treatment of)
Intervention: Intravascular ultrasound
Comparator: No intravascular ultrasound (incremental value)
Status:
ReportNumber:1032
Link to MSAC: click here

Laparoscopic adjustable gastric banding for morbid obesity

Type of evaluation:Systematic review and economic model
Patient population:Morbidly obese
Intervention: Laparoscopic adjustable gastric banding (LAGB)
Comparator: Roux-en-Y gastric bypass (RYGB) and vertical banded gastroplasty (VBG)
Status: Recommendations of the report were endorsed by the Commonwealth Minister for Health and Ageing on 7 September 2003.
ReportNumber:14
Link to MSAC: click here

Lymphoedema review

Type of evaluation:Horizon scanning Scope Review of current practices and future directions in the diagnosis, prevention and treatment of lymphoedema in Australia
Patient population:
Intervention:
Comparator:
Status: Report published February 2004.
Link to MSAC: click here

Magnetic resonance cholangiopancreatography

Type of evaluation:Diagnostic test evaluation, systematic review and economic model
Patient population:Suspected bile duct obstruction due to common bile duct stones or strictures
Intervention: Magnetic resonance cholangiopancreatography (MRCP)
Comparator: Endoscopic retrograde cholangiopacreatography (ERCP)
Status:
ReportNumber:25
Link to MSAC: click here

Magnetic resonance imaging for staging cervical and endometrial cancer

Type of evaluation:Diagnostic test evaluation and systematic review
Patient population:Cervical cancer and endometrial cancer
Intervention: Magnetic resonance imaging
Comparator: CT, ultrasound, clinical examination, biopsy
Status:
ReportNumber:7 b
Link to MSAC: click here

Optical coherence tomography

Type of evaluation:Systematic review and economic model
Patient population:Patients with suspected or confirmed macular degeneration, diabetic maculopathy or other retinal vascular diseases
Intervention: Optical coherence tomography
Comparator: Conventional imaging including fundus fluorescein angiography and computerised perimetry
Status: Considered by MSAC November 2008
ReportNumber:40
Link to MSAC: click here

Ostase

Type of evaluation:Systematic review and economic model
Patient population:Pagets disease of bone, renal osteodystrophy, prostate cancer and osteoporosis
Intervention: Ostase
Comparator: Total alkaline phosphatase (in Paget's disease) or as an incremental test for the other indications
Status: Recommendations of the report were endorsed by the Commonwealth Minister for Health and Ageing on 8 August 2003.
ReportNumber:1044
Link to MSAC: click here

Paediatric liver transplantation

Type of evaluation:Review of suitability as a nationally funded centre (systematic review searched only for existing systematic reviews or health technology assessments)
Patient population:Children with end-stage liver disease
Intervention: Paediatric liver transplantation
Comparator: not specified
Status: Considered by MSAC May 2007
ReportNumber:36 c
Link to MSAC: click here

Peritonectomy

Type of evaluation:Evaluation for suitability as a nationally funded centre
Patient population:Patients with pseudomyxoma peritonei and peritoneal mesothelioma
Intervention: Cytoreductive surgery with peritonectomy procedures and hyperthermic intraperitoneal chemotherapy
Comparator: Debulking ± systemic chemotherapy
Status: Considered by MSAC November 2006
ReportNumber:36 a
Link to MSAC: click here

Peritonectomy with heated intraoperative intraperitoneal chemotherapy

Type of evaluation:Evaluation for suitability as a nationally funded centre
Patient population:Patients with pseudomyxoma peritonei and peritoneal mesothelioma
Intervention: Peritonectomy and hyperthermic intraperitoneal chemotherapy
Comparator: Debulking ± systemic chemotherapy
Status: Considered by MSAC March 2010
ReportNumber:36
Link to MSAC: click here

Positron emission tomography for cervical cancer

Type of evaluation:Systematic review and economic model
Patient population:Patients with locally advanced, potentially curable cervical cancer or suspected recurrent cervical cancer or confirmed locally recurrent cervical cancer
Intervention: Positron emission tomography (PET)
Comparator: Prior tests without PET/CT
Status: Considered by MSAC March 2010
ReportNumber:35 e
Link to MSAC: click here

Positron emission tomography for epilepsy

Type of evaluation:Systematic review
Patient population:Patients with epilepsy refractory to medical treatment being considered for surgery
Intervention: Positron emission tomography (PET)
Comparator: Standard presurgical evaluation, including MRI and EEG
Status: Recommendations of the report were endorsed by the Commonwealth Minister for Health and Ageing on 2 March 2005.
ReportNumber:26
Link to MSAC: click here

Positron emission tomography for glioma

Type of evaluation:Systematic review and economic model
Patient population:Patients with suspected primary brain tumour or suspected residual or recurrent brain tumour
Intervention: Positron emission tomography (PET)
Comparator: No PET, biopsy or surgical excision
Status: Considered by MSAC March 2010
ReportNumber:35 d
Link to MSAC: click here

Positron emission tomography for head and neck cancer

Type of evaluation:Systematic review and economic model
Patient population:Patients with newly diagnosed or recurrent or residual carcinoma of the head and neck. Patients with metastatic squamous cell carcinoma involving cervical nodes from an unknown primary source.
Intervention: Positron emission tomography (PET)
Comparator: No PET or biopsy
Status: Considered by MSAC November 2008
ReportNumber:35 b(ii)
Link to MSAC: click here

Positron emission tomography for lymphoma

Type of evaluation:Systematic review and economic model
Patient population:Patients with Hodgkin lymphoma, aggressive non-Hodgkin lymphoma or indolent non-Hodgkin lymphoma.
Intervention: Positron emission tomography (PET)
Comparator: No PET, computed tomography or biopsy
Status: Considered by MSAC September 2009
ReportNumber:35 c
Link to MSAC: click here

Positron emission tomography for myocardial viability

Type of evaluation:Systematic review and economic evaluation
Patient population:Patients with chronic coronary artery disease and moderate to severe left ventricular systolic dysfunction
Intervention: Positron emission tomography (PET)
Comparator: Single-photon emission computed tomography or contrast enhanced magnetic resonance imaging or dobutamine echocardiography
Status: Considered by MSAC March 2010
ReportNumber:35 f
Link to MSAC: click here

Positron emission tomography for NSCLC and SPN

Type of evaluation:Systematic review (change in patient management and outcomes only)
Patient population:Patients with non-small cell lung cancer (update only) and solitary pulmonary nodule
Intervention: Positron emission tomography (PET)
Comparator: Standard care
Status: Recommendations of the report were endorsed by the Commonwealth Minister for Health and Ageing on 2 March 2005.
ReportNumber:16
Link to MSAC: click here

Positron emission tomography for oesophageal and gastric cancer

Type of evaluation:Systematic review and economic model
Patient population:Patients with biopsy-proven, potentially curable oesophageal or primary gastric cancer
Intervention: Positron emission tomography (PET)
Comparator: No PET or biopsy
Status: Considered by MSAC June 2008
ReportNumber:35 b(i)
Link to MSAC: click here

Positron emission tomography for recurrent colorectal, melanoma and ovarian cancer

Type of evaluation:Systematic review and economic model
Patient population:Patients with colorectal liver metastases, suspected locoregional recurrence of colorectal or ovarian cancer or metastastic recurrence of melanoma
Intervention: Positron emission tomography (PET)
Comparator: Conventional imaging including computed tomography (CT) (incremental value)
Status: Considered by MSAC August 2007
ReportNumber:35 a
Link to MSAC: click here

Positron emission tomography for sarcoma

Type of evaluation:Systematic review and economic model
Patient population:Patients with sarcoma (suspected, biopsy proven, residual or recurrent) or gastrointestinal stromal tumours
Intervention: Positron emission tomography (PET)
Comparator: Prior tests without PET/CT
Status: Considered by MSAC March 2010
ReportNumber:35 d
Link to MSAC: click here

Pulmonary thromboendarterectomy

Type of evaluation:Evaluation for suitability as a nationally funded centre
Patient population:Patients with chronic thromboembolic pulmonary hypertension
Intervention: Pulmonary thromboendarterectomy
Comparator: medical therapy (warfarin) ± lung transplantation
Status: Considered by MSAC November 2006
ReportNumber:36 d
Link to MSAC: click here

Selective dorsal rhizotomy

Type of evaluation:Review of suitability as a nationally funded centre
Patient population:Patients with cerebral palsy and spastic diplegia
Intervention: Selective dorsal rhizotomy
Comparator: Combinations of physiotherapy, orthotics, casting, lower limb Intramuscular botulinum toxin type A injections, and orthopaedic surgery
Status: Considered by MSAC November 2006
ReportNumber:36 b
Link to MSAC: click here

SIR-Spheres for the treatment of non-resectable liver tumours

Type of evaluation:Systematic review and economic model
Patient population:Patients with: 1. non-resectable, non-ablatable hepatic metastases secondary to colorectal cancer; 2. non-resectable, non-ablatable hepatocellular carcinoma
Intervention: SIR-Spheres ± chemotherapy
Comparator: 1. HAC treatment/ systemic chemotherapy; 2. transarterial chemoembolisation (TACE) or iodine-131lipiodol
Status: Recommendations of the report were endorsed by the Commonwealth Minister for Health and Ageing on 28 November 2005.
ReportNumber:1082
Link to MSAC: click here

Transurethral needle ablation for benign prostatic hyperplasia

Type of evaluation:Systematic review and economic model
Patient population:Symptomatic benign prostatic hyperplasia
Intervention: Transurethral needle ablation (TUNA)
Comparator: Transurethral prostatectomy (TURP)
Status:
ReportNumber:1014
Link to MSAC: click here

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