Background and eligibility
may not be eligible?
Most preterm babies have the umbilical cord clamped within 10
seconds of birth. Placental transfusion is a simple way of giving
the baby extra blood at birth by delaying the clamping of the
umbilical cord by 60 seconds or more.
There is promising evidence from randomised trials that
placental transfusion in babies less than 37 weeks of pregnancy may
improve their blood pressure, reduce the number of blood
transfusions needed and decrease bleeding into the brain, bowel
disease and infection. However, we not know if babies born before
30 weeks of pregnancy benefit or if placental transfusion increases
or decreases death or childhood disability. Despite this
uncertainty more doctors are recommending that all very preterm
babies are given a placental transfusion at birth. It is important
to find out if placental transfusion does more good than harm,
before it becomes even more widely used.
Download a copy of the protocol
Who is eligible?
- mother considered likely to deliver < 30 weeks of
gestation (29 6 weeks)
- informed consent has been received from a parent
Who may not be
You may not be eligible if there is an indication or
contraindication to placental transfusion, in view of parent or
doctor. Contraindications may include but not limited to
- fetal haemolytic disease
- fetal hydrops
- major malformations considered incompatible with survival
Evaluation of severe disability will be assessed by a short
paediatric questionnaire when participants are 18 - 24 months of
age. These data can be filled out from routine hospital assessments
including for example the Ages and Stages questionnaire.
One of the following is required in order to determine severe
- Ages and Stages score indicative of developmental delay
- Cerebral Palsy
- Major problems with language or speech
The study will keep in touch with parents via phone calls and
post to send updates, birthday wishes and generally for the study
to maintain contact.
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