Biospecimens are often collected from consenting patients and
stored in biobanks for future, unspecified research purposes.
Tissue may be collected from consenting patients during biopsy,
fine-needle aspirate procedures or surgery. The tissue may be
processed and stored as formalin-fixed paraffin-embedded blocks or
slides; as fresh-frozen material ('snap frozen' in liquid
nitrogen); or stored using other preservation methods.
Peripheral blood may be collected from consenting patients and
processed for recovery of components including serum, plasma, buffy
coat and other derivatives.
Biospecimens are stored at hospital sites or at dedicated
biobanking facilities in Australia or overseas. For our
studies, biospecimens collected from patients are linked to the
patient's clinical data collected during the clinical trial. This
is usually detailed clinical information including clinical outcome
data, such as overall survival, and occurrence of clinical
events being studied. Data from laboratory studies on the
biospecimens, combined with the clinical trial data, provides an
invaluable resource for translational research.
T1 studies (integrated laboratory and clinical
research) must have the approval of a human research ethics
Access to biospecimens
Access to biospecimens for research purposes is by application
- the specific Trial Management Committee and
- the Trials Group (eg Collaborative Trials Groups in the area of