Lisa Askie

PhD MPH BN NICC RM RN

Associate Professor Askie leads the Systematic Reviews and Health Technology Assessment team at the NHMRC Clinical Trials Centre which manages the Australian New Zealand Clinical Trials Registry, includes an MSAC evaluation group, hosts two Cochrane Collaboration entities (Breast Cancer Review Group and Prospective Meta-analysis Methods Group) and has an extensive test evaluation research program. 

Lisa's clinical background is in perinatal medicine and she has worked in healthcare systems in Asia, Australia, the UK and USA. She has Masters and Doctoral qualifications in epidemiology from the Faculty of Medicine, and is a Senior Research Fellow and an NHMRC Career Development Fellow at the University of Sydney. 

A/Prof Askie has a long standing interest in the conduct and methodology of clinical trials and systematic reviews. She has been involved with the Cochrane Collaboration since 1996 as a systematic review author and trainer. Lisa is the co-convenor of the Cochrane Prospective Meta-analysis Methods Group and member of the Cochrane Methods Editorial Board. A/Prof Askie was awarded an NHMRC Sidney Sax postdoctoral fellowship to Oxford where she undertook a meta-analysis of antiplatelets to prevent pre-eclampsia using individual patient data from over 38,000 women. She and her team are currently involved in nine international individual patient data and prospective meta-analysis collaborations. A/Prof Askie has published over 40 scientific papers and is a member of various health and academic advisory boards.

• Systematic reviews
• Meta-analysis
• Health technology assessment
• Individual participant data meta-analysis
• Prospective meta-analysis
• Prospective trial registration
• Clinical trials
• Evidence based medicine
• Clinical practice guidelines
• Perinatal medicine

• Invited member, NHMRC Grant Review Panel - large scale clinical trials (2011)
• Invited member, NHMRC Scholarships Review Panel (2011)
• Invited executive panel member. Antenatal magnesium sulphate prior to preterm birth for neuroprotection of the fetus, infant and child - NHMRC approved national clinical practice guidelines  (2009-2011)
• Invited member, Sample size and data safety monitoring committee sub-committee, International Forum for Standards for Research in Children (2009-present)
• Invited member, Scientific Advisory Committee, German Clinical Trials Registry (2008-present)
• Invited member, Scientific Advisory Committee, Pan African Clinical Trials Registry (2008-present)
• Invited member, World Health Organization International Clinical Trials Registry Platform Best Practice Group (2006-present, Chair 2009-2010)
• Member, Research Committee, NHMRC Clinical Trials Centre, University of Sydney (2007-present)
• Member, Neonatal Executive Committee, NHMRC Clinical Trials Centre,UniversityofSydney(2006-present)
• Member, Australian New Zealand Clinical Trials Registry Operational Executive Committee (2005-present)

Key publications

1. Askie LM, Ballard RA, Cutter G, Dani C, Elbourne D, Field D, Hascoet J, Hibbs AM, Kinsella JP, Mercier J, Rich W, Schreiber MD, Srisuparp P, Subhedar NV, Van Meurs KP, Voysey M, Barrington K, Ehrenkranz RA, Finer N, on behalf of the Meta-Analysis of Preterm Patients on inhaled Nitric Oxide (MAPPiNO) Collaboration.  Inhaled nitric oxide in preterm infants: an individual patient data meta-analysis of randomized controlled trials.Pediatrics2011; 128(4): 729-739.
2. Askie LM. Australian New Zealand Clinical Trials Registry: history and growth.Journal of Evidence Based Medicine2011; 4: 185-187.
3. Dear RF, Barratt A, McGeechan K,Askie L, Simes J, Tattersall MHN. Landscape of cancer clinical trials in Australia: using trial registries to guide future research.Medical Journal of Australia2011; 194(8): 387-391.
4. Dear R, Barratt A,Askie L, McGeechan K, Arora S, Crossing S, Currow D, Tattersall M. Adding value to clinical trial registries: insights from Australian Cancer Trials Online, a website for consumers.Clinical Trials2011; 8: 70-76.
5. Askie LM, Brocklehurst P, Darlow BA, Finer N, Schmidt B, Tarnow-Mordi W. NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol.BioMed Central Pediatrics2011; 11:6.
6. Askie LM, BaurLA, Campbell K, Daniels L, Hesketh K, Magarey A, Mihrshahi S, Rissel C, Simes RJ, Taylor B, Taylor R, Voysey M, Wen LI, on behalf of the EPOCH Collaboration. The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis [study protocol].BioMed Central Public Health2010; 10:728.
7. F Cools,LM Askie, M Offringa, JM Asselin, SA Calvert, SE Courtney, C Dani, DJ Durand, DR Gerstmann, DJ Henderson-Smart, N Marlow, JL Peacock, JJ Pillow, RF Soll, UH Thome, P Truffert, MD Schreiber, P Van Reempts, V Vendettuoli, G Vento, on behalf of the PreVILIG Collaboration. Elective high-frequency oscillatory versus conventional ventilation in preterm infants: a systematic review and meta-analysis of individual patients' data.Lancet2010; 375(9731):2082-91.
8. Cools F, Henderson-Smart DJ, Offringa M,Askie LM. Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants.Cochrane Database of Systematic Reviews2009, Issue 3. Art. No.: CD000104
9. Soon YY,Askie LM, Stockler MR, Boyer, MJ. Duration of chemotherapy for advanced non-small cell lung cancer: a systematic review and meta-analysis of randomized trials.Journal of Clinical Oncology2009, 27(20):3277-83.
10. Askie LM, Henderson-Smart DJ, Ko H. Restricted versus liberal oxygen exposure for preventing morbidity and mortality in preterm or low birth weight infants.Cochrane Database of Systematic Reviews2009, Issue 1. Art. No.: CD001077. DOI: 10.1002/14651858.CD001077.pub2
11. Grobler L, Siegfried N,Askie L, Hooft L, Tharyan P, Antes G. National and multinational prospective trial registers.Lancet2008; 372: 1201-1202.
12. Askie LM, Duley L, Henderson-Smart DJ, Stewart LA, on behalf of the PARIS Collaborative Group. Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data.Lancet2007; 369(9575): 1791-1798.
13. Askie L, Ghersi D, Simes. Prospective registration of clinical trials.Australian Journal of Physiotherapy2006; 52(4): 237-239. Impact Factor: 1.709; Times cited: 1.
14. Hopewell S, Clarke M,Askie L. Reporting of trials presented in conference abstracts needs to be improved.Journal of Clinical Epidemiology2006; 59(7):681-684.
15. Askie LM. Involving neonatal nurses in the Cochrane Neonatal Review Group.Neonatal Paediatric and Child Health Nursing2005; 8(3):19-21.
16. Askie LM, Henderson-Smart DJ, Jones R. Management of infants with chronic lung disease of prematurity in Australasia.Early Human Development2005; 81(2):135-142.
17. Askie LM. Oxygenation and outcomes in neonates. Invited editorial ineNeonatal Review; April 2004;1(8).
18. McInnes E, Askie LM.Evidence review on older people's views and experiences of falls prevention strategies.Worldviews in Evidence-based Nursing2004; 1:1-18.
19. Askie LM. Appropriate levels of oxygen saturation for preterm infants.Acta Paediatrica Suppl2004; 93(444):26-28.
20. Askie LM, Tin W. The use of oxygen in neonatal medicine: half a century of uncertainty.NeoReviews2003; 4(12): e340.
21. Askie LM, Henderson-Smart DJ, Irwig L, Simpson JM. Oxygen-saturation targets and outcomes in extremely preterm infants.N Engl J Med2003; 349(10): 959-967.
22. Lloyd J,Askie LM, Smith J, Tarnow-Mordi WO. Supplemental oxygen for the treatment of prethreshold retinopathy of prematurity.Cochrane Database of Systematic Reviews2003, Issue 2. Art. No.: CD003482. DOI: 10.1002/14651858.CD003482.
23. Simmer K,Askie LM. Preterm formula milk versus term formula milk for feeding preterm or low birth weight infants (Protocol).Cochrane Database of Systematic Reviews2003, Issue 2. Art. No.: CD004204. DOI: 10.1002/14651858.CD004204.
24. Foster J, Todd D, Bidewell J,Askie LM. Pulse oximetry measures compared for neonates <28 weeks' gestation.Neonatal, Paediatric and Child Health Nursing2002; 5 (2): 5-10.
25. Askie LM, Henderson-Smart DJ. Early versus late discontinuation of oxygen in preterm or low birth weight infants.Cochrane Database of Systematic Reviews2001, Issue 4. Art. No.: CD001076. DOI: 10.1002/14651858.CD001076.
26. Askie LM, Henderson-Smart DJ. Gradual versus abrupt discontinuation of oxygen in preterm or low birth weight infants.Cochrane Database of Systematic Reviews2001, Issue 4. Art. No.: CD001075. DOI: 10.1002/14651858.CD001075.
27. Askie L. The use and validity of surrogate endpoints.Australasian Epidemiologist2000; 7 (4): 33.
28. Kuschel CA, Evans N, Askie L, Bredemeyer S, Nash J, Polverino J. A randomized trial of enteral feeding volumes in infants born before 30 weeks gestation. Journal of Paediatrics and Child Health 2000; 36(6): 581-586.

Link to more CTC publications by Lisa Askie