John Simes

• BSc (Med) (hons I), University of Sydney
• MB BS (hons I), University of Sydney
• SM (Master of Science in Biostatistics), Harvard University
• FRACP
• MD: 'Cancer clinical trials: statistical clinical and ethical issues', University of Sydney

Professor John Simes is Senior Principal Research Fellow and founding director of the NHMRC Clinical Trials Centre. He co-leads a team of 150 who collaborate with clinical investigators and other researchers nationally and internationally in a research program aimed at improving health practice and health outcomes through better use of clinical trials research.

Prof Simes has taken leading roles in the establishment and growth of several collaborative trials groups, and has helped develop the clinical trials expertise of future leaders in the field through mentoring and teaching.

Professor Simes has substantively contributed to over 300 peer-reviewed articles, with many having a significant impact on current knowledge and clinical practice.

Professor Simes also practices as a medical oncologist at Royal Prince Alfred Hospital, and is Professor of Clinical Epidemiology, Faculty of Medicine, University of Sydney. He has taught medical students and postgraduate students at the University of Sydney since 1989.

He has received the Harvard Alum Award (Biostatistics), Harvard University (2009) in recognition of his work in research and the Medical Oncology Group of Australia's Cancer Achievement award for 2010 for lifetime achievement in oncology.

• clinical trials methodology, including risk modelling and use of surrogate outcome measures
• incorporation of quality of-life and cost-effectiveness studies in randomised trials
• decision analysis
• prospective meta analysis
• integrating trial evidence with the goal of improving clinical practice and health outcomes
• statin therapies to prevent CVD events
• patient preferences in cancer trials

• NHMRC Academy
• Scientific Advisory Committee, NHMRC CTC
• ANZ Clinical Trials Registry Advisory Committee
• LIPID study management committee, Long-term Intervention with Pravastatin in Ischaemic Disease (LIPID)
• FIELD management committee and executive, Fenofibrate Intervention and Event Lowering in Diabetes (FIELD)
• Scientific Advisory Committee, ANZ Breast Cancer Trials Group
• Scientific Advisory Committee, Australasian Gastro-Intestinal Trials Group (AGITG)
• Scientific Advisory Committee, Cooperative Trials Group for Neuro-Oncology (COGNO)
• Cholesterol Treatment Trialists Collaboration (joint coordinator)
• Virtual Coordinating Centre for International Collaborative Cardiovascular Research
• INSPIRE steering committee chair (International Trials of Aspirin to Prevent Recurrent Venous Thrombo-embolism)
• Safety and Data Monitoring Committee, Intensive Blood Pressure Reduction for Acute Cerebral Haemorrhage Trial: the INTERACT Trial
• Safety and Data Monitoring Committee, Kanyini GAP Polypill Study (George Institute)
• Trial Management Committee, Sentinel Biopsy versus Axillary Clearance (SNAC) Trial
• Trial Management Committee, ASPIRE trial (Aspirin to Prevent Recurrent Venous Thrombo-embolism)
• Trial Management Committee, BOOST II Trial (Benefits Of Oxygen Saturation  Targeting)
• Trial Management Committee, MAX Study (Mitomycin C, Avastin and Xeloda in metastatic colorectal cancer)

Link to publications by John Simes