PERINATAL TRIALS REPORT

PT0538

Efficacy and side effects of iron supplements for the vorrection of anaemia in pregnant women: a comparison of high dose vs low dose iron

Plain Language Summary:     Iron deficiency anaemia is a common problem in pregnancy. It is oftten treated with high dose iron that cause constipation, stomach cramp and inhibit zinc absorption. Despite these concerns, there are no studies designed to work out the best dose of iron to treat anaemia in pregnancy. The aim of the study is to determine the dose that is most effective for the treatment of anaemia with least side effects. Three doses of iron (20mg/d, 40mg/d and 80mg/d) will be tested, and haemoglobin response and gastrointestinal side effects will be assessed as the primary outcome.

Trial status:                         Open to accrual

Date trial opened to accrual:    28 January 2004

Expected accrual period:         Until April 2005

Trial Objective:

To determine the dose of iron that is most effective for treating anaemia in pregnant women with least gastrointestinal side effects by comparing 3 doses of iron supplementation with either 20mg/day or 40mg/day or 80mg/day.

Type of administration:        Single centre

Prinicipal Investigator/s:     Dr Maria Makrides

                                        Ph 61 8 8161 6067

                                        Email makridesm@mail.wch.sa.gov.au

Contact Person/s:             As above

© IMPACT/PSANZ 2001