PERINATAL TRIALS REPORT

PT0390

Prevention of low systemic blood flow and brain injury in very preterm babies using Milrinone.

Plain Language Summary:      Low blood flow to the body and brain is common in the first 24 hours after preterm birth. This is significantly related to brain haemorrhage and abnormal development at 3 years of age. Clinical markers of low flow are inaccurate and the drugs currently used to improve blood flow don't work in about 40% of babies. This trial will examine a new preventative approach to this low blood flow using a drug that has been successfully used in newborns after heart operations, Milrinone. The aim will be to prevent low blood flow and ultimately brain injury in preterm babies.

Trial status:                         Open to accrual

Date of opened to accrual:   1/03/2002

Trial Objective:                   

To demonstrate the safety and efficacy of Milrinone given to very preterm infants at risk of low systemic blood flow.

Type of administration:        Multi-centre National

Principal Investigator/s:        Dr Nick Evans

Contact Person/s:               To be advised

© IMPACT/PSANZ 2001