PERINATAL TRIALS REPORT

PT0368

COIN Trial: Nasal CPAP (continuing positive airways pressure) or lntubation for very preterm infants at birth. A randomised controlled trial.

Plain Language Summary:      The standard treatment of very premature babies has been intubation and ventilation at birth. Recent non-randomised studies have shown that some of these babies can be managed with oxygen provided under a low continuous positive pressure into the nose and that this may improve some of their outcomes. This trial will be the first randomised trial to compare these two treatments and determine which has the optimal outcome for the baby.

Trial status:                         Open To Accrual

Date trial opened to accrual:    1 February 2001

Expected accrual period:         Until 2006

Trial Objective:

To compare CPAP with Intubation for very preterm infants at birth in terms of mortality and other indicators.

Type of administration:       Multi-centre international

Principal Investigator/s:      

Professor Colin Morley

Ph 61 3 9344 2527 

Email: colin.morley@wch.org.au 

Dr Peter Davis

Ph 61 3 9344 2524

Contact Person/s:            

Linh Ung

Ph 61 3 93442609

Email: coin.trial@rwh.org.au

© IMPACT/PSANZ 2001